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Job Opportunities

Cytokinetics’ openings, when available, are listed below. If you see an opportunity that appeals to your area of expertise, please click on the associated link to learn more about that position.

Business Development

Department: Business Development

Job Location: South San Francisco

As a leader in muscle biology research, we are dedicated to our mission of improving the lives of people confronting devastating diseases of impaired muscle function. We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving the lives of people with debilitating diseases in which muscle performance is compromised and/or declining. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop the next generation of novel small molecule drugs specifically engineered to increase muscle function and contractility.

 

Responsibilities:

In conjunction with and reporting to the Sr. Vice President of Business Development, the Associate Director, Business Development and Alliance Management will focus on building value through strategic alliances and/or licensing transactions.

The responsibilities for this position involve serving as a cross-functional leader working in close coordination with key senior staff and consultants (e.g., within Commercial Development, Intellectual Property and Legal Affairs, Finance, Project Management and R&D) and engaging with our partners and potential partners at all levels.

 

This individual will:

  • Serve as a key contact for existing partners and on the team responsible for identifying, evaluating, negotiating, and executing new strategic alliances and/or licensing transactions
  • Participate in Cytokinetics’ strategic planning process
  • Develop and maintain strong internal and external relationships to facilitate effective execution of business development campaigns, including due diligence, terms development and negotiation
  • Ensure effective partnership governance and planning
  • Provide guidance to others working on Cytokinetics’ partnerships and lead initiatives to enhance business development and alliance management capabilities

 

Qualifications:

  •  A minimum of 7 years of post-baccalaureate experience in the biotechnology/pharmaceutical industry is required
  • Advanced degree (e.g., M.B.A., J.D., Ph.D., etc.) with a relevant technical degree
  • Track record of productive participation in a business development or alliance management role
  • Experience with negotiating and/or managing contractual relationships, including firm understanding of IP/licensing fundamentals
  • Excellent analytical capabilities, strong interpersonal and communication skills, demonstrated creativity, flexibility and problem-solving ability, solid knowledge base regarding business development and alliance management practices and trends, and proven ability to work effectively in a team environment with interactions across multiple, diverse disciplines

 

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

*Title will be commensurate with experience

 

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer

 

Submit your resume online now.

Discovery Biology

Department: Discovery Biology

Job Location: South San Francisco

As a leader in muscle biology research, we are dedicated to our mission of improving the lives of people confronting devastating diseases of impaired muscle function. We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving the lives of people with debilitating diseases in which muscle performance is compromised and/or declining. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop the next generation of novel small molecule drugs specifically engineered to increase muscle function and contractility.

 

We seek a highly motivated Senior Research Associate to join our Discovery Biology group.

 

Responsibilities:

  • This individual will play a key role in assessing biochemical and/or cellular activity, as well as specificity and mechanism of action of candidate compounds
  • The candidate will also be involved in designing, optimizing, and implementing a wide-range of biochemical and cell-based assays
  • As a member of a multidisciplinary team, this person will work closely with team members to identify, characterize and advance compounds through research and pre-clinical development

 

Qualifications:

  • The position requires a BS/MS in biochemistry, cell biology or related field with a minimum of 8 years of research experience in a pharmaceutical, or biotechnology setting
  • Prior experience with independent execution of biochemical and/or cellular assays in support of lead optimization, including data analysis and reporting, is essential
  • Experience should also include various enzymatic assay formats and/or cell-based assays
  • Excellent skills in experimental design, data analysis, troubleshooting, use of microtiter plate readers, liquid handling devices, as well as an ability to effectively consult the primary scientific literature are required
  • The successful candidate has outstanding attention to detail, is a team player, enjoys working in a multi-disciplinary environment, and possesses excellent verbal and written communication skills
  • He/she will be a self-starter and highly flexible with a willingness to learn new techniques and adapt to shifting priorities
  • The ideal candidate will also have substantial experience with one or several of the following areas: biochemical and cell assay technologies, high throughput screening, culturing and assaying of primary (neuronal or muscle) cells, stable cell line production, protein expression, purification, and characterization. The successful candidate will possess excellent computer skills, including experience with technical software packages and databases

 

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

*Title will be commensurate with experience

 

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer

 

Submit your resume online now.

Discovery Technologies

Department: Discovery Technologies

Job Location: South San Francisco

As a leader in muscle biology research, we are dedicated to our mission of improving the lives of people confronting devastating diseases of impaired muscle function. We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving the lives of people with debilitating diseases in which muscle performance is compromised and/or declining. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop the next generation of novel small molecule drugs specifically engineered to increase muscle function and contractility.

 

Cytokinetics has been an avid and early adopter of technology platforms and we have a robust discovery infrastructure that is constantly being refined and optimized as new programs come online. As we continue to look towards bringing in newer technology solutions, we are looking for an individual to take on the role of an Automation Engineer within the Research and Development Technologies department. The department can be viewed as a “Measurements Group” with the primary responsibility of providing automated hardware and software solutions to measure/detect signals in assays. The individual will be responsible for interfacing with the scientists to help establish, improve/scale-up and automate processes and for deploying and managing the infrastructure.

 

Responsibilities:

  • Partner with scientists to understand the diverse drug discovery workflows underway and help optimize/accelerate processes through automation
  • Help identify the latest instrumentation and technology solutions to aid in the measurement of signals to address scientific questions
  • Design, procure, deploy and maintain the high-throughput screening infrastructure
  • Design, source components, assemble and deploy custom hardware solutions to address and alleviate unique laboratory workflow problems
  • Interface with laboratory automation equipment such as robotic arms, liquid handlers, detectors, etc. to create scripts to execute processes. Help scientists create workflows on integrated automation platforms
  • Manage the hardware infrastructure within Research and function as a first responder for any instrumentation related issues
  • Routinely monitor the performance of instrumentation and function as an interface between scientists and OEM to schedule instrumentation maintenance and repairs

 

Qualifications:

  • BS/MS in a scientific or engineering/bioengineering discipline with a minimum of 5 years’ experience working in laboratory automation for the biopharmaceutical industry is required
  • Hands-on experience with system integration and laboratory equipment such as automated liquid handlers, robotic arms, plate readers, imaging platforms, LCMS, etc. is required
  • A strong passion for troubleshooting hardware problems is required
  • Experience in driving evaluation of new technologies by establishing plans and coordinating with the concerned stakeholders is required
  • Experience in working with scientists to develop/optimize assays is a plus
  • Experience with custom hardware design using 3D CAD packages such as Solidworks is a plus
  • Experience with commercial robotic integration platforms such as Green Button Go is a plus
  • Experience in software development techniques (.NET, LabVIEW, Python, etc) pertaining to process automation such as developing instrument drivers, customizing integration platforms, developing software tools to aid researchers, etc. is a big plus
  • The individual must be very motivated and have the ability to work independently and also very collaboratively
  • The individual must also possess strong communication and presentation skills.

 

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

*Title will be commensurate with experience

 

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer

 

Submit your resume online now.

Clinical Research

Department: Clinical Research

Job Location: South San Francisco

As a leader in muscle biology research, we are dedicated to our mission of improving the lives of people confronting devastating diseases of impaired muscle function. We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving the lives of people with debilitating diseases in which muscle performance is compromised and/or declining. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop the next generation of novel small molecule drugs specifically engineered to increase muscle function and contractility.

 

Reporting to the EVP Research & Development, the Director, Clinical Pharmacology will be responsible principally for early clinical drug development activities with a strong focus on Phase I and Phase IIa clinical trials. He/She will work closely with the Clinical Research Group and other members of the R&D team to ensure a strategic view is taken for the pipeline progression of individual projects.

 

Responsibilities:  

  • Design Phase I and Phase IIa clinical studies, including dose escalation, stopping rules and risk-benefit to ascertain that compounds are entered into man safely, efficiently and with scientific validity
  • Responsible for the medical content of clinical pharmacology studies
  • Responsible for the medical aspects of clinical pharmacology components related to regulatory documents and interact with regulatory authorities for all phases of drug development
  • Medical monitor in sponsored studies as appropriate, ensure that the clinical teams correctly handle all adverse events (AEs) and serious adverse events (SAEs) in accordance with ICH standards
  • Correctly apply the ICH and GCP regulations surrounding the primary activities of clinical development projects
  • Operate within the time and budget constraints of the clinical program
  • In collaboration with the Chief Medical Officer, train members of the product development team to enhance their skills
  • Communicate project-related information, including the planning and execution of meetings and presentations
  • Coordinate and complete scientific documents including protocols, clinical study reports, other regulatory documents
  • Travel up to 30% as necessary according to project needs

 

Qualifications:

  • MD, MD/PhD, or PharmD (Registered Medical Doctor preferred)
  • PhD in clinical pharmacology would be an asset
  • Board certification/specialist registration in clinical pharmacology highly desirable or significant prior relevant experience
  • At least 5 years of experience in drug development in the pharmaceutical and/or biotech industry, covering both early and translational phase development or significant participation in industry sponsored research as a clinical investigator
  • Randomized controlled clinical trial principles, methodology and procedures
  • Adverse medical event investigation, analysis, as well as reporting procedures and standards
  • FDA and EMA regulatory requirements and ICH/GCP guidelines is an asset
  • Federal and state regulations and guidelines pertaining to the conduct of clinical trials on human subjects
  • Statistical data collection, editing, validation and analysis techniques
  • Current and developing trends and standards in clinical trials monitoring
  • Industrial standards as applied to GCP and GLP
  • Infrastructure and operational characteristics of Contract Research Organizations (CROs) and centralized clinical laboratories
  • Ability to develop and implement clinical research monitoring plans and study specific procedures
  • Ability to establish data collection and management guidelines
  • Ability to communicate, interact and present competently and professionally both verbally and in writing at all levels within a broad, complex clinical research environment including third parties such as CRO’s and academia

 

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

 

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer

 

Submit your resume online now.

Pharmacology

Department: Pharmacology

Job Location: South San Francisco

As a leader in muscle biology research, we are dedicated to our mission of improving the lives of people confronting devastating diseases of impaired muscle function. We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving the lives of people with debilitating diseases in which muscle performance is compromised and/or declining. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop the next generation of novel small molecule drugs specifically engineered to increase muscle function and contractility.

 

We are looking for a postdoctoral research scientist in our Pharmacology Department with an interest in a career in pharmaceutical R&D.

 

Responsibilities:

  • The successful candidate will be involved in in vivo, in situ and ex vivo studies to characterize the pharmacodynamic effects of new drug candidates on skeletal and/or cardiac muscle function to support our drug discovery and development programs
  • The candidate will also be involved in research activities to establish biomarkers that may predict functional outcomes in non-clinical disease models
  • In addition, the candidate will have the opportunity to participate in project team meetings and to interact with colleagues of other disciplines within our research community

 

Qualifications:

  • PhD in physiology, pharmacology or a related discipline
  • Knowledge in fields of skeletal or cardiac muscle physiology, pharmacology, genetics and proteomics
  • Neuromuscular physiology experience is highly desirable
  • Experience in small and large molecule analysis by LC/MS/MS methodologies is a plus
  • Excellent written and verbal communication and presentation skills
  • Strong interpersonal and leadership skills
  • Ability to work within a multidisciplinary team

 

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

 

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer

 

Submit your resume online now.

Quality Assurance

Department: Quality Assurance

Job Location: South San Francisco

As a leader in muscle biology research, we are dedicated to our mission of improving the lives of people confronting devastating diseases of impaired muscle function. We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving the lives of people with debilitating diseases in which muscle performance is compromised and/or declining. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop the next generation of novel small molecule drugs specifically engineered to increase muscle function and contractility.

 

The Associate Director/Director, Clinical Quality Assurance (CQA) will be responsible for providing GCP and compliance related advice to internal clinical study teams and as well as maintaining CQA confidential files and SOPs. This position will coordinate clinical study related audits (e.g., Clinical Sites, Clinical Vendors, and internal clinical functional areas and systems) for compliance with Good Clinical Practices (GCP), study protocols and instructional documents, regulations and other applicable standards. He/She will ensure appropriate GCP-related and Inspection Awareness training is made available for internal staff. This position is also expected to assist clinical sites conducting Cytokinetics’ studies to successfully host regulatory inspections and also assist in hosting or supporting GCP and Drug Safety/Pharmacovigilance (DS/PV) regulatory inspections at Cytokinetics.

 

Responsibilities:

Oversight of Clinical QA daily operations for GCP compliance, oversight of contract auditors, and the quality of all deliverables including:

  • Oversee and perform day-to-day CQA activities
  • Assign CQA attendees to Study Management Team (SMT) meetings; Attend SMT meetings and provide compliance-related advice as needed
  • Ensure Audit Plans are created for Cytokinetics-sponsored clinical trials in compliance with internal SOPs; Approve audit plans when assigned this activity
  • Ensure that audits are conducted in compliance with Audit Plans and internal SOPs
  • Assign qualified GCP internal and contract auditors to perform GCP-related audits; ensure documentation of qualifications for each GCP auditor including CV of education and experience and training on associated SOPs is filed in CQA files
  • Co-audit with assigned auditors as needed to evaluate quality of audit activities an compliance with internal SOPs. Perform and report GCP-related audits when necessary
  • Review GCP-related audit reports in a timely manner for consistency in description of findings and classification of seriousness (Critical, Major, Minor) in compliance with CQA SOPs. Provide feedback to the assigned auditors and approve audit reports before finalization
  • Ensure audit findings are discussed with internal stake holders and provide compliance perspective regarding classification of findings
  • Provide audit findings to Clinical Vendors and internal stake holders per CQA SOPs and track resolutions to completion
  • Maintain CQA confidential audit files, schedules, and audit plans
  • Trend audit findings; create Audit Trends reports
  • Perform biennial review of CQA SOPs and create new CQA or revise existing CQA SOPs as needed. Approve CQA SOPs in the absence of the Sr. Director, CQA
  • Review and approve new and revised SOPs describing the responsibilities and activities of GCP functional areas
  • Provide formal compliance opinions providing interpretation of SOPs, regulations, and regulatory authority guidance
  • Collaborate with other QA colleagues to ensure GCP training and Inspection Awareness/Readiness training are performed at Cytokinetics at least annually and track participation
  • Work across departments to set priorities for GCP-related audits and Inspection Awareness/Readiness
  • Act as back-up inspection host or back-room support as assigned for any GCP-related or DS/PV inspection performed at Cytokinetics
  • Create/approve plans and site training for use during clinical site inspection training. Assist clinical sites to respond to regulatory inspections associated with Cytokinetics-sponsored clinical trials
  • Assist in creating Cytokinetics’ responses to GCP-related or DS/PV inspections at Cytokinetics
  • Remain current in regulatory requirements and industry standards for GCP
  • Perform annual personnel reviews of internal auditors

 

Qualifications:

  • BS/MS/Ph.D. in science, nursing, or other education with strong experience; minimum of 6 to 10 years’ experience working in FDA-regulated clinical research including at least 3 to 5 years Clinical QA
  • Keen understanding of the key requirements for compliance of clinical research and Drug Safety as described in Regulatory Authority (e.g., FDA and European) regulations and guidance, including ICH
  • The technical ability to critically analyze and synthesize compliance-related information and present the associated risks
  • Ability to coordinate internal and contract auditors and communications to audited entities (e.g., clinical investigators, clinical vendors, and internal staff)
  • Experience auditing Phase I-III clinical trials
  • Experience in hosting or supporting GCP-related or Drug Safety/Pharmacovigilance-related regulatory inspections
  • Excellent writing and editing skills
  • Ability to work independently, manage multiple priorities, and execute on goals
  • Excellent interpersonal communication skills

 

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

*Title will be commensurate with experience

 

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer

 

Submit your resume online now.

Regulatory & Compliance

Department: Regulatory & Compliance

Job Location: South San Francisco

As a leader in muscle biology research, we are dedicated to our mission of improving the lives of people confronting devastating diseases of impaired muscle function. We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving the lives of people with debilitating diseases in which muscle performance is compromised and/or declining. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop the next generation of novel small molecule drugs specifically engineered to increase muscle function and contractility.

 

The Senior/Principal Medical Writer will be responsible for collaborating with a number of departments in writing, reviewing and preparing a variety of technical documents, including: protocols/amendments, investigator brochures, consent forms, annual reports, DSURs, final study reports, and sections of INDs and NDAs. While the focus will be in the clinical and regulatory areas, the ability to assist with preparation of CMC documentation and drafts of scientific publications is a strong plus. The Senior Medical Writer will coordinate document preparation with a team of writers, as needed.

 

Responsibilities:

  • Draft high-quality clinical & regulatory documents that demonstrate a good grasp of the scientific and medical content and drug development process with excellent understanding of data analysis, data management and regulatory submissions
  • Work across departments to help set priorities for document preparation and collaborate on document content
  • Coordinate and manage consulting writers as needed
  • Work with service providers as needed for delivery of high quality documents
  • Write clinical abstracts, posters, and manuscripts
  • Review and edit documents prepared by other authors
  • Maintain document history and manage version control of documents
  • Provide guidance for style guides for document preparation
  • Keep current with relevant therapeutic area(s)

 

Qualifications:

  • BS/MS/Ph.D. with minimum of 8 years’ experience working as a Medical Writer in the biotech/pharmaceutical industry
  • The technical/scientific ability to critically analyze, synthesize, and present complex information in well-constructed documents
  • Keen understanding of the key requirements for regulatory submissions as stipulated in FDA and ICH guidelines for preparation of INDs, CTXs, NDAs and MAAs
  • Ability to coordinate and manage communications to enable timely reviews from other authors and reviewers and to function as a collaborative team member
  • Ability to coordinate other writers in the preparation of complex submissions
  • Experience with Phase I-III clinical trials including international regulatory requirements
  • Proficiency with medical terminology and ability to articulate drug development data, process, and regulatory submissions
  • Expertise regarding Clinical Study Report (CSR) and appendices
  • Experience with event and drug coding dictionaries (MedDRA, Who Drug Dictionary)
  • Knowledge and experience with CMC sections of INDs, NDAs, and other submissions is a strong plus
  • Skilled with software applications and document management systems, including experience with document templates
  • Excellent editing skills
  • Ability to work independently, manage multiple priorities, and execute on goals
  • Excellent interpersonal communication skills

 

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

*Title will be commensurate with experience

 

Please visit our website at: www.cytokinetics.com  

Cytokinetics is an Equal Opportunity Employer

 

Submit your resume online now.