Heart failure

Heart failure affects 64 million people worldwide, hospitalizes more Americans per year than all cancers combined, and is becoming more common as the overall population ages and heart attack survival rates increase.1,2,3 The prevalence of heart failure in the U.S. is expected to grow from almost 6 million to more than 8 million people by 2030 and the cost of care is expected to increase 120% to almost $70 billion.4

Heart failure is a progressive condition in which the heart becomes enlarged, thickened or rigid, causing it to become too weak or stiff to fill and pump blood throughout the body. Heart failure is the consequence of dysfunction within the sarcomere, a complex mechanism of interacting proteins driving heart contraction.

People living with heart failure may experience symptoms such as shortness of breath, fatigue, and coughing as they try to perform everyday activities. Heart failure has no cure, and needs to be actively managed and treated in order to slow its progression. Despite available treatments, many heart failure patients have difficulty managing their disease. Heart failure remains the leading cause of hospitalization and readmission in people age 65 and older.5 30 to 50% of heart failure patients either die or are re-hospitalized within 60 days of admission, and almost half die within five years of hospital discharge.4

By modulating sarcomere dysfunction by powering up cardiac muscle contractility, our investigational medicine may improve heart function and performance, potentially increasing lifespan in patients with heart failure.

  1. Savarese G, Lund LH. Global public health burden of heart failure. Cardiac failure review. 2017 Apr;3(1):7.
  2. Mamas MA, et al. Do patients have worse outcomes in heart failure than in cancer? European Journal Heart Failure 2017
  3. James et al. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Lancet 2018; 392: 1789–858.
  4. Mozaffarian D, et al Heart disease and stroke statistics-2016 update a report from the American Heart Association. Circulation. 2016.
  5. Heart Failure | National Heart, Lung, and Blood Institute (NHLBI). 2019. Available at: Accessed March 22, 2019.