Tirasemtiv, a Novel Activator of Fast Skeletal Muscle, Increases Isometric Force Evoked by Electrical Stimulation of the Anterior Tibialis Muscle in Healthy Male Subjects

American Academy of Neurology 2014 Annual Meeting
Philadelphia, PA
Hansen R, Saikali KG, Chou W, Russell A, Chen M, Vijayakumar V, Stoltz R, Baudry S, Enoka R, Morgans D, Wolff AA, Malik FI
April 2014

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator

American Journal of Respiratory and Critical Care Medicine
Hooijman PE, Beishuizen A, De Waard MC, De Man FS, Vermeijden JW, Steenvoorde P, Bouwman RA, Lommen W, Van Hees HW, Heunks LM, Dickhoff C
April 2014

Tirasemtiv Amplifies Skeletal Muscle Response to Nerve Activation in Humans

Muscle & Nerve
Hansen R, Saikali KG, Chou W, Russell AJ, Chen MM, Vijayakumar V, Stoltz RR, Baudry S, Enoka RM, Morgans DJ, Wolff AA
December 2014

Tirasemtiv (CK-2017357): A Fast Skeletal Muscle Troponin Activator for the Potential Treatment of ALS

2014 MDA Clinical Conference
Washington, DC
Andrews, JA
March 2014

The relationship between tirasemtiv serum concentration and functional outcomes in patients with ALS

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Shefner JM, Wolff AA, Meng L
December 2013