A Novel Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

Circulation: Heart Failure
He H, Baka T, Balschi J, et al
November 8, 2021

The Effect of Omecamtiv Mecarbil on Stroke in Patients With Heart Failure and Reduced Ejection Fraction in GALACTIC-HF

Presentation, American Heart Association (AHA) Scientific Sessions 2021
Teerlink, JR, et al
November 13, 2021

Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure

JAMA Cardiology
Felker GM, Solomon SD, Claggett B, et al
October 13, 2021

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

Journal of Medicinal Chemistry
Collibee SE, Bergnes G, Chuang C, Ashcraft L, Gardina J, Garard M, Jamison CR, Lu K, Lu P, et al.
October 12, 2021

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Journal of Medicinal Chemistry
Chuang C, Collibee S, Ashcraft L, Wang W, Vander Wal M, Wang X, Hwee DT, Wu Y, Wang J, Chin ER, Cremin P, Zamora J, Hartman J, Schaletzy J, Wehri E, Robertson LA, Malik FI, Morgan BP
October 4, 2021