A Novel Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Discovery of CK-274: A novel, small molecule, cardiac myosin inhibitor for the treatment of hypertrophic cardiomyopathies (HCM)

The Cardiac Myosin Inhibitor, CK-3772271, Attenuates Cardiac Fibrosis and Diastolic Dysfunction in the Dahl/Salt Sensitive Rat Model of Heart Failure with Preserved Ejection Fraction

Pharmacodynamic Effects of a Single Dose of CK-3773274 in Cats with Hypertrophic Cardiomyopathy

The novel myotrope, AMG 594, is a small-molecule cardiac troponin activator that increases cardiac contractility in vitro and in vivo

Characterization of the Cardiac Myosin Inhibitor CK-3773274: a Potential Therapeutic Approach for Hypertrophic Cardiomyopathy

The Cardiac Myosin Inhibitor, CK-3773274, Reduces Contractility in the R403Q Mouse Model of Hypertrophic Cardiomyopathy

Pharmacologic Characterization of the Cardiac Myosin Inhibitor, CK-3773274: A Potential Therapeutic Approach for Hypertrophic Cardiomyopathy