INNOVATING SARCOMERE-DIRECTED potential medicines

scientist testing potential medicines
scientists working in a laboratory

Pipeline

As a pioneer in muscle biology and the mechanics of muscle, we have developed a broad and diverse pipeline of cardiovascular and neuromuscular muscle-directed medicines with the potential to improve muscle function in diseases of impaired contractility.

See pipeline

Clinical Trials

At Cytokinetics we are committed to rigorous research to elaborate on the safety and efficacy of our potential medicines. Over our 25-year history, we have conducted more than 100 clinical trials in partnership with hundreds of research institutions across the world, and are grateful to the tens of thousands of patients who have contributed to our development programs.

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Heart Failure

Conducted 30+ clinical trials to assess the efficacy and safety of omecamtiv mecarbil in patients with heart failure with a reduced ejection fraction.

Heart Failure clinical trials

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Hypertrophic Cardiomyopathy

Evaluating the efficacy and safety of aficamten in a broad and expansive clinical trial program spanning obstructive and non-obstructive hypertrophic cardiomyopathy.

HCM clinical trials

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Amyotrophic Lateral Sclerosis

Conducted some of the largest clinical trials in ALS, culminating in the Phase 3 clinical trial, COURAGE-ALS.

ALS clinical trials

All drug candidates are investigational and are not approved by any regulatory agency. Their safety and effectiveness have not been established.

Publications

Poster, American Heart Association Annual Meeting (AHA)
Washington, DC
Niu C, Anderson RL, Cox DR, Morgan BP, Morgans Jr DJ, Malik F, Elias KA
November 2004

Poster, American Society of Cell Biology,
Washington, DC
Niu C, Anderson R, Cox D, Qian X, Morgan B, Malik F, Morgans Jr D, Elias K
December 2004

Poster, American Society of Cell Biology
Washington, DC
Niu C, Cox D, Lee K, Sylvester S, Sueoka S, Qian X, Feng B, Malik F, Morgans Jr D, Hartman J, Sakowicz R, Elias K
December 2004

American Society of Cell Biology
Washington, DC
Rodriguez H, Sylvester S, Qian X, Morgan B, Morgans Jr D, Malik F, Sakowicz R
December 2004

Poster, American Society of Cell Biology
Washington, DC
Rodriguez H, Sylvester S, Sakowicz R
December 2004

Poster, American Heart Association Council on Basic Cardiovascular Sciences
Keystone, CO
Malik F, Shen Y, Katori T, Sueoka SH, Anderson R, Cox D, Garard M, Hartman J, Kim S, Kraynack E, Kuklov A, Lee KH, Lu P, Muci A, Niu C, Rodriguez H, Suehiro I, Sylvester S, Tochimoto T, Elias KA, Morgan BP, Sakowicz R, Kass DA, Vatner SF, Morgans DJ
July 2005

Poster, Heart Failure Society of America Annual Meeting (HFSA)
Boca Raton, FL
Malik F, Elias KA, Finer JT, Morgan BP, Sakowicz R, Anderson R, Baliga R, Conn L, Cox D, Garard M, Hartman J, Irvine J, Kawas R, Kraynack E, Kuklov A, Lee KH, Lu P, Muci A, Pierce DW, Rodriguez H, Suehiro I, Sueoka SH, Sylvester S, Tochimoto T, Valdez C, Wang W, Katori T, Kass DA, Shen YT, Vatner SF, and Morgans DJ
September 2005

Poster, American Society of Cell Biology (ASCB)
San Francisco, CA
Lenzi D, Fritsch A, Alexander G, Hansen R, Cong G, Zink W, Godinez G, Pham A, Trautman J, Pierce DW, Malik F, Finer JT
December 2005