PUTTING MUSCLE BEHIND OUR mission
We are committed to developing potential medicines that may improve the healthspan of people living with cardiovascular and neuromuscular diseases of impaired muscle function.
Some of these life-altering diseases include heart failure, hypertrophic cardiomyopathy (HCM disease), and amyotrophic lateral sclerosis (ALS).
By impacting the mechanics of muscle with investigational medicines that may improve muscle strength, power, or performance, we aspire to develop new medicines that may improve patient outcomes for people living with these debilitating diseases.
The Science of Muscle
At Cytokinetics our research is focused to modulating proteins in the sarcomere, the fundamental unit of muscle contraction found within muscle cells. These crucial proteins are the keys to unlock the potential treatment of diseases that are caused by impaired muscle function.
Heart Failure (HF)
Heart failure is a progressive condition in which the heart becomes enlarged, thickened or rigid, causing it to become too weak or stiff to fill and pump blood throughout the body.
Hypertrophic Cardiomyopathy (HCM)
HCM is a progressive condition that causes the heart to thicken. The thickened walls may become stiff, reducing the amount of blood taken in and pumped out of the body with each heartbeat.
Neuromuscular Disease
Neuromuscular diseases impact the nerve cells that send messages from the brain and spinal cord to muscles throughout the body, often resulting in muscle weakness or loss.
References
- Murphy SP, Ibrahim NE, Januzzi JL. Heart failure with reduced ejection fraction: a review. JAMA. 2020;324(5):488-504.
- Frailties and critical issues in neuromuscular diseases highlighted by SARS-CoV-2 pandemic: how many patients are still "invisible"?. Acta Myologica. 2022.