Omecamtiv Mecarbil
Omecamtiv mecarbil is designed to directly target the contractile mechanism, or pumping function of the heart.
Aficamten
Cardiac myosin inhibitor
Aficamten is an investigational, oral, small molecule cardiac myosin inhibitor. It was designed to reduce the hypercontractility associated with HCM by blocking myosin from pulling, resulting in less contraction, or fewer hands on the rope. In preclinical models, aficamten reversed and reduced thickening and stiffening of the heart.
Aficamten is currently the subject of SEQUOIA-HCM (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM), a pivotal Phase 3 clinical trial in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM), MAPLE-HCM (Metoprolol vs Aficamten in Patients with LVOT Obstruction on Exercise Capacity in HCM), a Phase 3 clinical trial evaluating aficamten as monotherapy compared to metoprolol as monotherapy in patients with obstructive HCM, and ACACIA-HCM (Assessment Comparing Aficamten to Placebo on Cardiac Endpoints In Adults with Non-Obstructive HCM), a pivotal Phase 3 clinical trial in patients with symptomatic non-obstructive HCM.
Learn more about clinical trials for aficamten
Aficamten is an investigational product and is not approved by any regulatory agency. Safety and effectiveness have not been established.
Discover our other drug candidates
Reldesemtiv
Reldesemtiv is an investigational fast skeletal muscle troponin activator for the potential treatment of amyotrophic lateral sclerosis (ALS).
CK-136
CK-136 is an investigational cardiac troponin activator for the potential treatment of patients with heart failure with reduced ejection fraction (HFrEF).
References
- 1. Heart Failure | National Heart, Lung, and Blood Institute (NHLBI) [Internet]. Nhlbi.nih.gov. 2019. Available at: https://www.nhlbi.nih.gov/health-topics/cardiomyopathy. Accessed March 22, 2019.
- 2. Maron, MS, Hellawell, JL, Lucove, JC, Farzaneh-Far, R and Olivotto, I (2016). “Occurrence of clinically diagnosed hypertrophic cardiomyopathy in the United States.” The American journal of cardiology 117(10): 1651-1654.