Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a disease in which the heart muscle becomes abnormally thick or enlarged. The thickening of cardiac muscle leads to the inside of the left ventricle becoming smaller and stiffer, and it becomes less able to relax and fill with blood. This ultimately limits the heart’s pumping function, resulting in symptoms including chest pain, dizziness, shortness of breath, or fainting during physical activity. Some patients with HCM are at high risk of progressive disease which can lead to atrial fibrillation, stroke and death due to arrhythmias. There are no current medical treatments that directly address the hypercontractility that underlies HCM.1

HCM is the most common inherited cardiovascular disorder, affecting approximately 1 in 500 individuals worldwide. However, only about 1 in 3,200 people in the United States are diagnosed with HCM and experience symptoms.2

  1. Heart Failure | National Heart, Lung, and Blood Institute (NHLBI) [Internet]. 2019. Available at: Accessed March 22, 2019.
  2. Maron, MS, Hellawell, JL, Lucove, JC, Farzaneh-Far, R and Olivotto, I (2016). “Occurrence of clinically diagnosed hypertrophic cardiomyopathy in the United States.” The American journal of cardiology 117(10): 1651-1654.