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339 results available

The Effects of the Cardiac Myosin Activator, Omecamtiv Mecarbil, on Cardiac Function in Systolic Heart Failure: a Double-blind, Placebo-controlled, Crossover, Dose-ranging Phase 2 Trial

The Lancet
Cleland JG, Teerlink JR, Senior R, Nifontov EM, Mc Murray JJ, Lang CC, Tsyrlin VA, Greenberg BH, Mayet J, Francis DP, Shaburishvili T
August 2011
Dose-dependent Augmentation of Cardiac Systolic Function with the Selective Cardiac Myosin Activator, Omecamtiv Mecarbil: a First-in-man Study

The Lancet
Teerlink JR, Clarke CP, Saikali KG, Lee JH, Chen MM, Escandon RD, Elliott L, Bee R, Habibzadeh MR, Goldman JH, Schiller NB
August 2011
Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension

The Journal of Pharmacology and Experimental Therapeutics
Zhao X, Ho D, Abarzúa P, Dhar SK, Wang X, Jia Z, Pannirselvam M, Morgans DJ, Malik FI, Vatner SF
October 2011
Bilateral Concentric Heel Raise Test: A Novel Functional Endpoint for Early Stage Clinical Trials in Peripheral Artery Disease (PAD)

Poster, 22nd Annual Sessions of the Society for Vascular Medicine
Boston, MA
Bauer TA, Hirsch AT, Malik F, Wolff AA, Hiatt WR
June 2011
Efficacy and Tolerability of the Novel Fast Skeletal Muscle Troponin Activator, CK-2017357, in Patients with Claudication

Poster, 22nd Annual Sessions of the Society for Vascular Medicine
Boston, MA
Hiatt WR, Hirsch AT, Bauer TA, Malik F, Lee J, Lin Y, Han FX, Chen MM, Jones D, Cedarbaum JM, Wolff AA
June 2011