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391 results available

Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

ACS Medicinal Chemistry Letters
Morgan BP, Muci A, Lu PP, Qian X, Tochimoto T, Smith WW, Garard M, Kraynack E, Collibee S, Suehiro I, Tomasi A
August 2010
Quantitative Evaluation of Drug or Device Effects on Ventricular Remodeling as Predictors of Therapeutic Effects on Mortality in Patients With Heart Failure and Reduced Ejection Fraction: A Meta-Analytic Approach

Journal of the American College of Cardiology
Kramer DG, Trikalinos TA, Kent DM, Antonopoulos GV, Konstam MA, Udelson JE
July 2010
CK-2017357, a Novel Activator of Fast Skeletal Muscle, Increases Isometric Force Evoked by Electrical Stimulation of the Anterior Tibialis Muscle in Healthy Male Subjects.

Poster, XII International Congress on Neuromuscular Diseases
Naples, Italy
Chou W, Hansen R, Saikali KG, Russell A, Chen MM, Vijayakumar V, Stoltz R, Baudry S, Enoka R, Morgans D, Wolff AA, Malik F
July 2010
Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs with Systolic Heart Failure

Circulation: Heart Failure
Shen YT, Malik FI, Zhao X, Depre C, Dhar SK, Abarzúa P, Morgans DJ, Vatner SF
July 2010
The Direct Smooth Muscle Myosin Inhibitor, CK-2018571, Represents a Novel Therapeutic Mechanism for Bronchodilation

Poster, American Thoracic Society’s 2010 International Conference
New Orleans, LA
Jia Z, Godinez G, Durham N, Wang X, Chuang C, Lu P, Wang W, Yao B, Warrington J, Clancy S, Hartman JJ, Morgans DJ, Morgan BP, Qian X, Malik FI, Pannirselvam M
May 2010