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341 results available

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator

American Journal of Respiratory and Critical Care Medicine
Hooijman PE, Beishuizen A, De Waard MC, De Man FS, Vermeijden JW, Steenvoorde P, Bouwman RA, Lommen W, Van Hees HW, Heunks LM, Dickhoff C
April 2014
Tirasemtiv Amplifies Skeletal Muscle Response to Nerve Activation in Humans

Muscle & Nerve
Hansen R, Saikali KG, Chou W, Russell AJ, Chen MM, Vijayakumar V, Stoltz RR, Baudry S, Enoka RM, Morgans DJ, Wolff AA
December 2014
Tirasemtiv (CK-2017357): A Fast Skeletal Muscle Troponin Activator for the Potential Treatment of ALS

2014 MDA Clinical Conference
Washington, DC
Andrews, JA
March 2014
The relationship between tirasemtiv serum concentration and functional outcomes in patients with ALS

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Shefner JM, Wolff AA, Meng L
December 2013
A study to evaluate safety and tolerability of repeated doses of tirasemtiv in patients with amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Shefner JM, Watson ML, Meng L, Wolff AA, Neals/Cytokinetics STUDY Team
December 2013